Iranian Research Organization for Science and Technology Advances in Environmental Technology 2476-6674 6 2 2020 04 01 Development and validation of a gas chromatography-tandem mass spectrometry analytical method for the monitoring of ultra-traces of priority substances in surface waters 69 81 1010 10.22104/aet.2021.4460.1246 EN Luca Amendola ARPA Lazio, Regional Agency for Environmental Protection; via G. Saredo 52, 00173 Rome, Italy Maria Teresa Saurini ARPA Lazio, Regional Agency for Environmental Protection; via G. Saredo 52, 00173 Rome, Italy Elisa Lancia ARPA Lazio, Regional Agency for Environmental Protection; via G. Saredo 52, 00173 Rome, Italy Maria Cortese ARPA Lazio, Regional Agency for Environmental Protection; via G. Saredo 52, 00173 Rome, Italy Silvia Zarrelli ARPA Lazio, Regional Agency for Environmental Protection; via G. Saredo 52, 00173 Rome, Italy Ilaria De Angelis ARPA Lazio, Regional Agency for Environmental Protection; via G. Saredo 52, 00173 Rome, Italy Lucia Schenone ARPA Lazio, Regional Agency for Environmental Protection; via G. Saredo 52, 00173 Rome, Italy Sara Evangelista ARPA Lazio, Regional Agency for Environmental Protection; via G. Saredo 52, 00173 Rome, Italy Francesco Di Girolamo ARPA Lazio, Regional Agency for Environmental Protection; via G. Saredo 52, 00173 Rome, Italy Journal Article 2020 10 22 The 2013/39/EU Directive of the European Parliament provided a list of substances (organic and inorganic compounds); these so-called priority and dangerous priority substances affect the quality status of surface waters. Due to their high level of toxicity, these contaminants have legal limits in the order of µg/L and even some in the order of ng/L and pg/L. To this aim, an effective and sensitive analytical method for monitoring these contaminants was deemed necessary. In this experimental process, a highly effective workflow represented by a pre-analytical and an analytical phase was developed and validated. The pre-analytical phase comprises a liquid-liquid microextraction and a quick, easy, cheap, effective, rugged, and safe purification. The analytical part was performed by a very sensitive and robust multi-residual GC-MS/MS method without the need for derivatization. This method simultaneously identified and quantified most of these substances (represented by pesticides, chloroalkane hydrocarbons, and polycyclic aromatic hydrocarbons) at very low concentration levels while respecting the analytical concentration limits required by the European directive. https://aet.irost.ir/article_1010_1e48c4420b7073bc11916c6c1de226bb.pdf